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We used the Nelder-Mead or Simplex method46 to find the local minimum values of the target functions.
The required values of the target parameters and the experimental values were compared.
Log P values of the target compounds indicates good penetration to CNS.
Colours indicate the normalized values of the target functions (according to the colour scale on the right) for different values of the free parameters.
The resolution values of the target compounds were used as responses in the screening and optimisation phases.
The result is a set of blends that match the constraints, the compositions, values of the target properties and information about their miscibility.
The result is a set of blends that match the constraints, the composition of the chemicals present in the blend, and the values of the target properties.
The numerical values of the target parameters (size, depth, location and resistivity) are estimated in three steps consisting of conventional regularized inversion, exclusion of anomalous regions and delineation of target bodies.
Therefore, the exception Ex was selected as the prediction values of the target.
Therefore, trial runs were performed with the following values of the target factor: 20-80 with steps of 20.
In this case, the mean and standard deviation of the converted pitch contour match the mean and standard deviation of the pitch values of the target speaker.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com