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Next, Clune et al. allowed various digital organisms, with various values of the mutation rate, to compete against each other.
In all implementations of the model, a high level of historical contingency was observed for intermediate values of the mutation parameter μ.
The weighted degree values of the mutation and drug-target based cancer networks are not strongly correlated (Pearson correlation coefficient of 0.37, p = 0.11).
We simulated the data under possible values of the mutation rate ranging from 0.01 to 0.2 mutations/site/myrs and assumed an average generation time of one year for Dicrostonyx torquatus [44].
In this paper we have focused on the study of the values of the mutation rates that promote maximal adaptation in a short number of generations when populations previously optimized at different error rates experience a single environmental shift.
The population evolves during 200 generations under 6 different values of the mutation rate (μ2 = 0.001, 0.002, 0.005, 0.01, 0.02, and 0.05) giving rise to the adapting populations (populations A) shown in Fig. 1.
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For mutation R723G, the fraction of mutated transcript was determined from the ratio of IOD/bp values of the mutation-specific 125-bp fragment versus the 156-bp fragment.
The fraction of mutated MYH7-mRNA was calculated based on the IOD/bp values of the mutation-specific 269-bp fragment versus the average of the two wild-type specific fragments of 146 and 123 bp.
The fact that chloroplast SSRs tend to support population expansion, rather than bottleneck, for population NW provides a further hint that the positive values of the mutation-drift equilibrium tests are due to selection rather than demography.
The best value of the mutation rate is 0.02 due to the lowest average fval value.
We performed r = 50 independent realizations of this process for each value of the mutation rate.
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