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The results display a remarkable spike in field strength, with sample mean values of over 120 μT (compared to the current field strength of 44 μT).
In particular, compounds 7a, 7b and 7d bearing electron-donating methoxy, methyl and 2,4-difluoro substitutions respectively gave excellent activities with EC50 values of less than 2.81 µM as well as SI values of over 122.
Image quality of the coronary CTA scans was high, with HU values of over 325 in the coronary arteries.
Images of non-traumatised slices showed a sharp, well-defined peak at gray scale values between 20 and 75 (darker background coloured portions of the image) falling rapidly to near zero at gray scale values of over 75.
However, despite their promising in vitro activity, these compounds have Clog P values of over 5.
Heat exchanger effectiveness reaches values of over 50% for unmixed beds and over 80% for perfectly mixed beds for an optimal choice of parameters.
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The most statistically significant values of over-expression were obtained for A1, followed by A3.
Note that, while these motifs are over-represented, the modest values of over-representation make their biological relevance subject to interpretation.
This collection of genomic resources includes the disease regulome, which shows the relation between TFs and diseases in the form of ≈450000 values of over-/under-representation for specific combinations of a TF and a disease.
Based on the selected test-statistic, normalized values of over-/under-representation are computed and visualized (see Figure 1 for a schematic representation of the strategy and Methods for details).
While the dynamic lists provide direct access to z-score values of over-/under-representation, the heat map representation allows a broader overview of results, providing powerful visual clues of the most deviant associations, and also providing a broad impression of similarities and differences between specific TFs/diseases of interest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com