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The agreement and kappa values of concordance of TST and IGRA have been reported widely in TB contacts [ 9, 15, 26].
Each pair shows private sites that are heteroplasmic in CENT and CO with variable values of concordance but different between pairs.
These same authors studied the validity of fracture coding within the British GPRD database [ 12] and found slightly higher values of concordance both with GP questionnaires and with discharge summary than we report here.
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Random effects meta-analysis results can be summarized by the mean concordance probability and a 95% prediction interval for possible values of the concordance probability.
The datasets in this group are also associated with higher values of the concordance index when used for validation.
In addition to descriptive statistics for each question, the statistical analysis included the calculation of kappa values for concordance between awareness and actual practice of withholding or withdrawal of specific treatments in each scenario and for concordance in responses across scenarios.
For statistical inference of the concordance function, we set the critical threshold of T-values for concordance to a value equivalent to the joint distribution of atrophy and perfusion at p < 0.05 statistical significance with a family-wise error (FWE) adjustment for multiple comparisons, as illustrated in Fig. 1.
The kappa statistic measures the extent of exact agreement, adjusting for chance agreement with values greater than 0.75 representing excellent concordance; values of 0.40 to 0.75 representing moderate concordance; and values less than 0.40 representing poor concordance [ 15].
Data from an actual ideal experiment (0% contamination) had on average correlation values of 0.89 and concordance values of 0.41.
In theory this should result in better estimates for the confidence intervals, but here we observed that, particularly for low values of prevalence and concordance rates, there were computational problems ('code red'), and failure notices, which made inference unreliable.
Array (observed) variants are included in these metrics summaries and are given imputation r, genotype concordance, and MA concordance values of 1.
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