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These different study populations assume different target populations for genetic profiling, and the predictive value will differ between these populations when disease risks, genotype frequencies and effect sizes are different.
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The approaches are based on different assumptions, different statistical tests are used and statistical significance (p-values) will differ.
It has not been shown whether utility values will differ in middle-income countries because of the differences in lifestyle, preventive measures, access to health care, health care delivery system, social values, illness experiences and perceptions of ill health.
Values will differ between a supporter of the Green party and a voter for Angela Merkel's ruling conservative party, the Christian Democratic Union (CDU).
Note that these values will differ if the mode and second largest observed levels of education are separated by fewer than 15 percentage points.
The figure gives a good idea of what amount of data that is needed to reach a specific accuracy level for the classifiers, but please note that the although the shape of the curves is similar also for other number of users, the exact values will differ.
For both approaches, the challenges of eliciting values will differ according to age groups: infant, preschool, school-age, and adolescent.
But where to set the threshold between normal variation and ADHD (or obesity) that deserves treatment is up to human beings, whose perspectives and values will differ.
These values are compatible with the known biology of myeloma and the outcome will not change because their absolute values will differ from the ones that we chose to illustrate these dynamics.
This means that a mechanical stimulus, applied during the ECG QRS complex, but even more so during the T-wave, will not affect cells uniformly, as 'local AP' values will differ regionally across the heart.
Whatever value we hold that makes for a good or virtuous life, that value will necessarily differ in different people, at different times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com