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The second mechanism, introduced by Lefevre et al. [17], operates at cell level, either projecting or nullifying the value of each cell.
We computed the integration value of each cell by using the analysis tools in space syntax and visualized the values with colors.
This class of association measures is determined by (1) a model for the expected value of each cell in the contingency table and (2) the function of the ratio of observed-to-expected.
The value of each cell is the aggregate scaled activity of a chemical-NR pair, and the column intensities signify the aggregate NR activity profile for each chemical (see Methods).
The cost value of each cell ranged from 1 5096, where an elevation of 1 m above sea level was assigned a cost of 1 and an elevation of 2300 m was assigned a cost of 5096 following the exponential equation y = 1.4142 e 0.0035x.
Then, the discrete value of each cell is concatenated with the respective column index.
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The overall weighted mean surface roughness was calculated as: where is the mean of the four values on each cell i, and each mean value is weighted by a factor 1/σi2 where σi2 is its standard deviation.
The standard deviation of the relative risk values of each cell was calculated and used to identify areas of high sensitivity.
The individual IC50 values of each cell line are presented in Supplementary Table 1.
TAM at the IC50 values of each cell lines also caused cell shrinkage, and the cells lost their adherence and showed membrane blebbing as in Figure 5E (a-d).
The comparable range and median expression values of each cell subpopulation among all cell lines verified the objectivity of ALDH1 quantification irrespectively of the specific breast cancer subtype and allowed its application on patient samples.
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