Sentence examples for value linkage from inspiring English sources
While this number of markers may seem too small to be of any value, linkage disequilibrium in this population is quite extensive in comparison to humans [22] or cattle [23], and there is substantial clustering of SNPs [24], so many adjacent SNPs are correlated.
On the basis of pooled p values, linkage disequilibrium structure of the region, and location in regions with transcriptional properties, SNPs were selected for replication.
Clustering of the data was performed using the following parameters: the distance between objects in the data matrix was one minus the sample correlation between points (treated as sequences of values), linkage was set to complete (furthest distance), and the cutoff within the dendogram for the hierarchical cluster tree was set to 0.50.
On the basis of the "modest" value for linkage and multiple phenotypes under consideration, some of the regions detected with suggestive linkage in either study may also correspond to false positive results.
The R2 value of linkage disequilibrium was calculated for all possible marker pairs within each chromosome.
Based on the r value, the linkage between the various parameters was developed as follows: significance (0.8 ≤ r ≤ 1.0); moderate (0.6 ≤ r < 0.8) and less significant (0.5 ≤ r < 0.6).
To detect the small-effect QTL, the threshold value of linkage was set as P = 0.05 (Chi-square test).
To identify these potential small-effect QTL, we reanalyzed the data using a lower threshold value of linkage (P = 0.05).
Most of these genomic regions did not reach a genome-wide significant threshold value of linkage, with P values between 0.05 and 0.001 [ 1- 5].
This suggests that there must be other susceptibility genes whose contributions were not big enough to reach the stringent significance threshold value of linkage analysis.
In the case of a sufficiently large positive value of linkage disequilibrium (D' > 0.9), the polarization mark is assigned to 1, whereas in the case of a sufficiently large negative linkage disequilibrium (D' < -0.9) the polarization mark is assigned to -1.
