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Remarkably, after the krona lost more than half its face value, inflation is also coming down quite sharply.
By robbing a currency of its value, inflation wipes the slate clean for debtors and savers alike.
Whatever the motives, the combined loss of sales threatens an economy already reeling, where the currency has plummeted in value, inflation has surged and the general public has expressed growing anxiety about the prospect of war.
The peso has lost 35% of its value; inflation has nearly doubled from last year, to 9.5%; and unemployment is exceeding 10%.
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We ran TRIBE-MCL with all possible combinations of E-value and inflation value (32 E-values ×39 inflation values = 1,248 runs).
The genomic control inflation factors for GWASs of each SC type were checked for potential p-value inflation.
The genomic inflation factor, λ, was 1.0345, 1.0055 and 1.0125 for three meta-analyses, respectively, indicating negligible P-value inflation.
Three parameters (E-value, inflation factor, and a new parameter called "coverage") were evaluated and adjusted to optimize the performance [Additional file 2].
However, comparison of these association results with standard association tests (no correction for population structure) revealed very little evidence of P-value inflation due to population structure in our cohort (Additional file 3: Figure S2).
As previously observed for the PROP and quinine-detection-threshold phenotypes, OTS correction only boosted the most significant SNPs (Fig. 4a and Supplementary Material, Fig. S3c) and no overall P-value inflation was observed (lambda before = 1.0272 lambda after = 1.0493).
The Manhattan plot of the discovery GWA analysis in MICROS is given in Figure 1A together with the quantile quantile (QQ) plot to illustrate the level of potential P-value inflation (Fig. 1B).
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CEO of Professional Science Editing for Scientists @ prosciediting.com