Thus, the derived kon value incorporates the overall binding process and does not give insights on the detailed mechanism, which for Ca2+ ions, may be quite complex, as evident by the wide range of association rates found in the organic and inorganic world.
EA value incorporates the effect of changes in geometry between the (gas-phase) anion and neutral species, whereas ELUMO and VDE do not account for geometry changes.
This value incorporates the known constant of 11.3 seconds for the indicator to transit the arterial catheter to the electrode (manufacturer's data), with published data from healthy volunteers suggesting that indicator transit from the margin of the thorax to the wrist would result in a delay of no more than 2.0 seconds [ 18].
Using the Bland-Altman formula [ 24], the average bias and its associated 95% limits of agreement (LoA), which equates to approximately 1.96 multiplied by the standard deviation, delineate the overall measuring error of the GlucoRx TD-4280 BG meter; this value incorporates the presence of both random errors and any systematic deviations between the different measurement methods used.
The addition scheme was no more than ten times the average response of OPAHs in either method, with most responses within a factor of 3. Estimates of variability for standard addition values incorporated the standard deviation of both the slope and intercept of each regression model as described in Bader 1980 [ 32].
Feather CORT integrates the intensity and frequency of the physiological response because values incorporate the amplitude and duration of all CORT secretion, including response to stressors, during the period of feather growth [60], [61].
That is, the calculation of a P-value incorporates the sample size, as well as the magnitude of the association.
These simulated values incorporate the error term from the conversion model plus an additional perturbation to account for uncertainty in the conversion model parameters.
The titration procedure is described in detail, along with a program for calculating p Ka′′ values incorporating the ionization of water in octanol.
The actual versus regression model predicted values (incorporating the statistical effect of the factors outlined above) for HbA1c (8.6 ± 1.8 vs. 8.6 ± 0.6%) and fructosamine (313 ± 74 vs. 313 ± 33 µmol/L) were not significantly different and the crude values were thus used throughout.
