Positive predictive value for current recommendations was calculated for the those aged >60 years; men with markers of iron deficiency and a haemoglobin <11.0 g dl−1 had a PPV of 13.3% (CI 9.7, 18) and women with a haemoglobin <10.0 g dl−1 had 7.7% (5.7, 11).
The cut-off value for each recommendation was extracted from the PAMP recommendations; when the recommendation includes (all patients) we considered the cut-off value to be 100% of patients and this applied to recommendations 1 4.
The lowest values were observed for recommendations 5 and 8 (mean 0.3 (0.9) and 0.3 (1.2), respectively).
However, the presentation of the results throughout the paper will be done only by children and adolescents, but fitting them in their corresponding reference value for water intake recommendations.
Beyond that, an aggregated index would be of limited value for decision-makers, because recommendations for action have to address particular fields of action which can't be identified based on an aggregated index, but need disaggregated information provided in terms of specific indicators and targets.
Without knowing the causal variants, such analyses may provide a limited interpretive value for prevention strategies or recommendations for vitamin D supplementation.
The highest values were 1.4 (1.8), for recommendation 4 ("non-pharmacological treatment of AS"), 1.1 (1.6), for recommendation 2 ("disease monitoring of patients with AS") and 1.0 (2.0), for recommendation 9 ("anti-tumour necrosis factor (TNF)").
Our positive predictive value 2 (recommendation for tissue diagnosis or PPV2) was 43%, as illustrated in Fig. 2.
Our positive predictive value 2 (recommendation for tissue diagnosis or PPV2) was 43%, which is exactly the same value as in BCSC for palpable findings (43%), above the value of BCSC Benchmarks for non-palpable findings (31%), and near the value requested by BIRADS for non-palpable findings (15 40%) and by BIRADS for palpable findings (25 50%).
The interviews explored the facilitators and barriers that users experienced in implementing GE M their perceptions about the ease of use and usefulness of the GE M the perceptions about the degree of alignment between the GEM and the users' values, and; recommendations for improving the GEM and promoting its sustainability.
