Based on the hypergeometric distribution, we found that the enrichment in genes with promoters similar to histone genes is statistically significant (p-value of 2.12E-55, and corrected p-value for multiplicity testing of 7.13E-51; withypergeometricic parameters of N=33,596, n=141, K=1,207, k=65), thereby validating our hypothesis.
Values for multiplicity are expressed as means ± SD.
Values for multiplicity are expressed as mean ± SE.
All statistical analyses were of exploratory nature, with no adjustment of P values for multiplicity.
No correction of p values for multiplicity of testing will be undertaken.
To adjust the P values for multiplicity Holm's procedure will be used [ 16].
We are aware of the large number of measures and statistical tests performed in our analysis, and thus use false discovery rate (FDR) methodology for adjusting p-values for multiplicity [ 60].
The results suggest that the bird assembly by the Newbler-454 team performed very well, with the highest levels of coverage and validity, and lowest values for multiplicity and parsimony among all competitive bird assemblies.
The conventional correction of P values for multiplicity aims to control the family-wise error rate, but it is often too conservative for the purposes of many biological studies.
SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) and Sense of Coherence (SOC) Nonparametric Kruskal-Wallis test, Mann-Whitney-U test; p-values less than 0.017 (Bonferroni correction of p-values for multiplicity) are shown in bold, p-values for Mann–Whitney-U are shown only where Kruskal-Wallis tests were significant; Wilcoxon signed rank test.
If either PCS and/or MCS scores of SF-36 were statistically significant, significance was tested for the individual domain scores, without P value corrections for multiplicity.
