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This further subdivision, however, is of limited practical value for guidance of treatment because embedding is critically dependent on the composition of the subendothelial plaque components and not correctable, unlike apposition, with appropriate sizing and expansion at higher pressure.
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Therefore, predictive markers, such as miRNAs, that can identify subgroups of patients who will benefit from chemotherapy will have great value for treatment guidance.
In addition, the value for money guidance can be a resource for the Global Fund (at the global level) and PRs (at the local level) to negotiate prices with those in the industry, by using its evidence as their guidance.
We suggest not only that cost-effective interventions be selected correctly from the value for money guidance, but also that HTA be applied to at least some aspects of a proposal before implementation.
Firstly, the Global Fund would be able to make better-informed interventions, due to the evidence garnered by HTAs and by complying with the HTA-informed value for money guidance.
Clearly, the value for money guidance issued on the back of an HTA can be a useful tool that PRs and CCMs can use to avoid investment in high-cost and low-impact options.
An ex-ante assessment can be used as a requirement for a CCM that does not select the cost-effective interventions in its proposal to demonstrate that the selected intervention(s) is at least as cost-effective in a given context if not more so than those reported in the value for money guidance.
For junior students, the value of guidance, advice and explanations from near peers is recognized in the literature [ 19, 25, 26] and this is apparent in our medical students.
Such data would be of value for providers of guidance to travellers and for clinical decision making.
Such wild type cutoff values are not intended for guidance of therapy and should not be confused with clinical breakpoints for resistance [ 7].
Owing to the large number of statistical tests, our P values should be used for guidance in interpretation rather than finality (see Supplementary Data for details on multivariate analysis).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com