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Suggested PIC value classes are: PIC > 0.5 (high polymorphism); 0.25 < PIC < 0.5 (moderate polymorphism) and PIC < 0.25 (low polymorphism) [ 27].
The five value classes of kinetic parameters may correspond to varying strengths of enzymatic reactions that can be measured and classified experimentally.
Doubling the number of value classes resulted in a similar, albeit finer, map of parameter motifs, but did not alter the conclusions reached (see Discussion).
On the whole, catalytic rate constants k FBB and k BA were biased towards the 3rd and the 4th value class, respectively, while all five Michaelis-Menten constants were biased towards one or more of the first three value classes.
To facilitate and simplify the comparison, we dictated that parameters with a value in the first three value classes (i.e., < 10) are small-value parameters, while those in the 4th and 5th value class (i.e. ≧10) are large-value parameters.
Finally, the above findings can be succinctly captured by drawing a kinetic-functionality network, which highlights both the functional roles and constraints (i.e. the enriched value classes) of kinetic parameters.
Similar(51)
It unsettles assumptions about art, originality and value, class and sexual difference and creativity.
Steven Resnick, a Manhattan tax lawyer, said that while Class 1 properties are assessed at 8percentt of market value, Class 2 properties are assessed at 45percentt.
Each instance in the training set contains one "target value" (class labels) and several "attributes" (features).
In more detail, the following validation results should be available for each predicted compound: Predicted endpoint value (class or numeric regression value).
Analogously, value class probabilities are refined using the core-weighted matrix (generated using equation 4).
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