For these reasons, there is no logical reason to think that the null hypothesis is likely to be false based solely on a small P-value; additional information is required.
Secondly, economic interpretation reveals that the value of additional information depends on two opposing effects.
When the signal affects an insurable risk, like in our model, the value of additional information depends on two opposing effects.
Marketing practitioners in particular might value the additional information offered by the md-IAT, for example allowing them to easily create complex and differentiated brand profiles, and thus distinguishing between different components of an overall brand attitude (i.e., tapping into the multifaceted nature of consumers' brand associations).
The potential value of additional information was found to be high beyond the willingness-to-pay threshold of £5,500.
However, the value of additional information obtained from a proxy-report advocate for its completion as well.
Registry data in its current form provide valuable information, but such data can be of greater value if additional information is collected.
In Additional file 1, we present other examples of discordance between the platforms, further illustrating the value of additional information present on the Exon Array in profiling both "whole transcript" and "isoform-level" changes.
This study has also shown that the value of additional information is potentially worthwhile and identified the QALY gain arising from the utility gain per unit increase in dBHL and the total gain in dBHL as the key uncertain parameters.
The use of VOI methods involved three necessary actions: (i) formation of decision-analytic model to describe the decision problem; (ii) stochastic illustration of the underlying decision uncertainties; and (iii) confirmation of the potential value of additional information from future study.
Systematic evaluation of all relevant evidence within an economic model will also allow explicit consideration of the expected value of additional information generated by future research, for example a prospective trial evaluating the clinical utility of UGT1A1 test, and whether that would outweigh the cost of undertaking the trial in the first place (Sculpher and Claxton, 2005).
