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The study will be the first to provide valuable efficacy and utility data on the use of r-CGM among people with T2D in primary care.
However, in clinical practice, targeted therapies are frequently combined with SSAs and there have been reports of valuable efficacy in heavily pretreated patients [ 21]; thus in a retrospective cohort, 83 % of 29 patients with well differentiated pNETs who were treated with sunitinib in daily practice in Spain also received concomitant treatment with SSAs [ 22].
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RITZ-4 will provide valuable safety and efficacy data with the novel compound tezosentan in patients with acute heart failure and acute coronary syndrome.
However, from extensive experience, the authors believe that evaluation of headache severity through migraine days is a more valuable measure of efficacy in clinical practice.
Antiangiogenic drugs are typically cytostatic in their mechanism of action and consequently tumor reduction may be a less valuable index of efficacy.
The AFUGEM trial is designed to provide valuable information regarding efficacy and tolerability of nab-paclitaxel plus gemcitabine and nab-paclitaxel plus sLV5FU2 regimens.
It is beyond any doubt that implementing and evaluating RCTs is still very much warranted, as the outcomes of these tightly controlled studies provide valuable information concerning efficacy and internal validity.
IGFBP3 is less sensitive to short-term nutritional variations and diseases than IGF-I and could therefore be valuable when monitoring efficacy of and compliance with GH treatment [ 38].
The selective regional brain volume loss is one of the key pathological features in N171-82Q HD mice and is a valuable measure of efficacy for treatment in preclinical trials.
Various prospective studies of glycemic outcomes in this population are underway or recently completed (Table 5), and their findings will provide further valuable safety and efficacy data about DPP-4 inhibitors in this group, and may also allow for additional pooled analyses of outcomes of interest such as fracture.
In studies of epilepsy treatment in humans post-marketing studies assessing the clinical use of a drug deemed an important tool, with the most valuable data on efficacy and safety thought to be obtained from prospective and retrospective studies that are monocentric, and gather information on long-term anti-epileptic drug therapy in a single centre only [ 1, 2].
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