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Even before the anthrax scare boosted demand, Cipro was one of the world's most valuable antibiotics, boasting worldwide sales of $1.6 billion last year.
Polymyxins are valuable antibiotics for use in patients in the intensive care setting.
Fermentation and downstream technologies are well developed for streptomycetes, which are industrially relevant microorganisms producing many valuable antibiotics and other bioactive metabolites [ 1]; thus they can be successfully further applied to improving and scaling-up VanYn production.
Modular type I polyketide synthases (PKSs) are giant multifunctional enzymes, principally from actinomycete bacteria, that use a remarkable assembly-line logic for the biosynthesis of a diverse array of bioactive natural products,[ 1] including a number of clinically valuable antibiotics, immunosuppressants, and anticancer compounds.
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Further, this potentially valuable antibiotic resistance research could help patient care teams stem a grim future where we experience a regression in health and life spans due to no longer having the ability to treat currently curable diseases.
There is a demand for generating high-producing strains for industrial production of this valuable antibiotic.
The same pasture operations that make for contented cows also protect air and water quality, sequester heat-trapping carbon and don't undercut the efficacy of valuable human antibiotics.
Such strategies aim to give companies assurance that they will make money if they bring valuable new antibiotics to market, regardless of the number of pills prescribed right away.
Actinoplanes teichomyceticus is the only known producer of the valuable glycopeptide antibiotic teicoplanin.
Such strategies may prolong the useful life span of this valuable class of antibiotics.
Bacteriocins produced by LAB have potential biomedical applications where they may provide valuable alternatives to antibiotics for the treatment of human and animal infections.
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