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Content validity ratio.
Content validity was assessed using the content validity ratio approach.
The Lawshe's content validity ratio (CVR) was calculated for each item and averaged for the total scale.
The following formula was used to compute the content validity ratio (CVR) based on the data provided by the expert panel. .
Table 1 Minimum (Min), Maximum (Max), Median (Me), Mean (M), Skewness (Sk), Kurtosis (Ku) and Content Validity Ratio (CVR) for the original 32 items tested (SE Sk = 0.138; SE Ku = 0.275).
The overall content validity ratio (Lawshe, 1975) was 0.80.
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The mean content validity index ratio was 0.98.
The overall content validity index ratio for the tool was 0.98 (Table 5).
Hence, if VT is considered to be at least moderately associated with brain TSPO levels in healthy subjects, the validity of ratio-based methods must be questioned.
We also investigated the interregional correlations for SUV and VT respectively, since the relationships between target and denominator regions, which both contain TSPO, may influence both the reliability and validity of ratio-based outcome measures.
These latter, even when random, have greater impact on the validity of ratio-type measures of association than false negative errors [ 23].
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