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One of the many ways in which the validity of this principle may be demonstrated is first to train blindfolded cats to discriminate with one paw between two different pedals (by feeling raised horizontal lines on one pedal and by detecting raised vertical lines on the other).
Inline lanthanide-binding peptide tags (LBTs) have been developed for binding to larger metal ions, such as gadolinium, demonstrating the validity of this principle.
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The current version of MisPred uses a variety of tools that were optimized for the analysis of proteins of Metazoa, but because the validity of this basic principle is not restricted to metazoan proteins, in our future work we will adapt the MisPred tools for analysis of proteins of other eukaryotes.
Whoever, as Chrisippus did, accepts the validity of the principle of bivalence, opts for two-valued logic; whoever even partially rejects this principle, as Aristotle did, thereby opens the door to many-valued logic.
We may also discuss the validity of the principle of Archimedes.
1908 First publication of his argument against the general validity of the Principle of the Excluded Middle in "The unreliability of the logical principles".
The validity of the first and the second law of thermodynamics, as well as the validity of the principle of maximum dissipation rate, are required.
According to Łukasiewicz, the Stagirite himself doubted the validity of the principle of excluded middle in the domain of future contingents.
It is easy to misunderstand Damian's position regarding the validity of the principle of non-contradiction and the possibility of altering the past.
While Abelard thought that the universal validity of the principle of bivalence was an Aristotelian view, thirteenth-century commentators argued for the traditional interpretation.
With such a reflexive turn in the debate about toleration, a number of questions arise as to the alleged superior validity of the principle of justification and the plausibility of a neo-Baylean epistemology distinguishing between faith and knowledge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com