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The soundness or validity of the results in the inverse modeling depends on a valid conceptualization of the groundwater system, validity of the basic hydrochemical concepts and principles, accuracy of input data into the model, and level of understanding of the geochemical processes in the area (Güler and Thyne 2004).
Kelsen, however, quite explicitly admits that efficacy is a condition of the validity of the basic norm: A basic norm is legally valid if and only if it is actually followed in a given population.
The validity of the basic norm, as we noted briefly earlier, is conditional on its "efficacy".
This puts an upper limit for the validity of the basic theory.
Existentialism does not deny the validity of the basic categories of physics, biology, psychology, and the other sciences (categories such as matter, causality, force, function, organism, development, motivation, and so on).
This is basically what was meant earlier by the comment that Kelsen had no option but to admit that the validity of the basic norm is conditional on its efficacy.
Similar(49)
One cannot say both that the basic norm is the norm presupposing which validates all inferior norms and also that an inferior norm is part of the legal system only if it is connected by a chain of validity to the basic norm.
Regardless of the absence of a survival benefit, the tumour MGMT activity results lend validity to the basic premise of the RTOG 0525 trial and other ongoing trials using dose-intense temozolomide regimens in the treatment of newly diagnosed or refractory glioblastoma.
The current version of MisPred uses a variety of tools that were optimized for the analysis of proteins of Metazoa, but because the validity of this basic principle is not restricted to metazoan proteins, in our future work we will adapt the MisPred tools for analysis of proteins of other eukaryotes.
Similarly, the normativity of law, presupposed by its basic norm, is optional: "An anarchist, for instance, who denied the validity of the hypothetical basic norm of positive law….
Recent experimental evidence seem to confirm the validity and usefulness of the basic assumption on which GRNs are resting.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com