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The validity of survival estimates may also depend on completeness of cancer registration (Monnet et al, 1998; Prior et al, 1998).
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The power (and indeed in some cases validity) of a survival analysis is related to the number of events rather than the number of participants.
The purpose of the present study was to assess the validity of the survival estimations in PD obtained by the Kaplan-Meier method compared to the competing risks method developed by Kalbfleisch and Prentice in a cohort of 383 PD patients.
However, losses to follow-up may threaten the validity of analyses of survival if the proportion of patients dying after HAART is high and only known deaths are counted as events.
In their study, 7 the overall survival benefit associated with the addition of cetuximab to radiotherapy relative to radiotherapy alone is remarkably similar to that seen in the 3-year analysis (45% vs 55%), which supports the validity of 3-year survival as a surrogate for long term overall survival.
The validity of disease-specific survival is based on the assumption that the underlying cause of death is accurately determined.
To develop a rule-based scheme for characterization of "frailty", for instance, Fried et al. [ 16] first developed a conceptual framework, devised a rule-based system within this framework, and then validated the predictive validity of the rule-based system using survival data from the Cardiovascular Health Study.
The validity of estimates obtained from survival models requires that several assumptions are met [59].
Our study together with a previous report (Lara et al, 2006) questions the validity of OR as a survival indicator.
As with other cancer statistics, the validity of population-based cancer survival estimates depends on the quality of the cancer registry data.
As a demonstration of the validity of the cause-specific survival analyses, we found that extent of the breast disease was strongly predictive of breast cancer mortality but it was not associated with endometrial cancer mortality.
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