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The present study was designed to investigate the validity of samples "spiked" with 25-hydroxyvitamin D2 [25(or)D25-hydroxyvitaminitamin D3 [25(OH)D3] to determine their analytical recovery by the DiaSorin LIAISON 25 OH Vitamin D Total Assay (DiaSorin Assay) and high-performance liquid chromatography (HPLC).
We use this model to examine the validity of sample-based estimates of the total burden of drug resistance and explore how the magnitude of bias in these sample-based estimates is affected by the maturity of the drug-resistant tuberculosis epidemic and the implementation of different types of public health interventions.
These results highlight the need for untargeted metabolite profiling in combination with accurate quantification of metabolites in order to evaluate the validity of sampling protocols.
It is important to examine the validity of sampling online compared to more established venue-based methods because the individuals recruited by sampling online may be fundamentally different from those recruited offline, with respect to their sexual risks.
Snowball sampling has been criticised for selection bias which limits the validity of the sample.
To determine the validity of the sample clustering based on the methylation data, a bootstrap test (10 000 sampling steps) was used to calculate the percentage of replicate trees in which the associated samples clustered together (Felsenstein, 1985).
In June 2012, we conducted a pre-test survey to affirm the validity of the sample and reconstructed the wording of our questions to ensure the questionnaire (Additional file 1) was clear and user-friendly.
To confirm the validity of T1D sample of 1.1 million patients in the MEPS, we apply the same T1D clinically-derived definitions that were described above to the NHANES data.
Therefore, those factors may have some bearing toward the validity of the sample representations.
This further underpins our findings supporting the validity of our sample frame.
These results can be generalised because of the high external validity of the sample study (recruited in primary care settings).
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