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Even though the validity of DAT imaging as a surrogate marker for clinical trial has been legitimately questioned [29], the reproduction of this mismatch in three independent investigations and using different markers (F-DOPA and β-CIT) suggests that factors other than the imaging technique may have influenced the outcomes.
Similar(59)
I will have some of dat green juice".
He launched into a frenetic performance of "Dat $tick".
As Robert Blake's Baretta character used to say, "That's da name of dat tune".
Yeah, "Get rid of dat damn bar! Blah, blah, blah".
And lots of functions and unrepentant shaking of dat ass.
"got to take care of dat nice body of yours and not git sick".
Finally, we used a combination of DAT immunohistochemistry (Fig. 8A C), DAT binding (Fig. 8D F) and DAT ISH (Fig. 8G I) on brain and spinal cord sections to determine whether TH-IR A11 neurons express DAT.
For DAT, there was a significant main effect of diagnosis (p = 0.001) but not of DAT genotype and DAT-diagnosis interaction.
MPH is a potent blocker of DAT receptors.
Thus, in the study by Kim et al. (2002) and in other SPECT and PET DAT imaging studies, it is possible that the decrease in DAT measured by SPECT may not be representative of DAT loss in the striatum (or, by inference, of dopamine terminal degeneration); rather, the decrease in DAT may reflect the ability of Mn to interfere with radioligand binding to DAT.
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