To test the validity of the consensus model, we asked if the consensus sequence is enriched in exonic or intronic sequences across the genome using composite exons [18].
The latter further confirms the validity of the consensus sequences.
All of these factors in turn could affect the reliability and validity of the consensus diagnosis.
While many studies have reported the validity of the Consensus criteria, implementation of the criteria in daily work has raised many practical questions.
The validity of a consensus is dubious, as dissidents are encouraged to alter their responses so as to better comport with the majority [ 2].
All these genes were significantly increased in Ercc1 and App-PsS1 microglia compared to controls, confirming the validity of the consensus primed microglia blue module.
To determine the external validity of the consensus exercise, the multi-disciplinary panel assessed a stratified random sub-sample of consultations (20 'yes/yes' and 10 'no/no' consultations) from each uni-disciplinary panel (60 consultations in total) using the same two questions.
To evaluate the usefulness and validity of the consensus PKW B-genome for expression studies, a total of 256 M paired-end, 100 bp RNA reads from two AAA, and three AAB cultivars, and one diploid Austalimusa Fe'i cultivar were mapped to the combined A- and B-genome sets.
These processes allowed identification of uncertainty and reasons for disagreement, and provided a strong foundation for the content validity of these consensus-based recommendations.
We negotiated the validity of these decisions to consensus based on Sandelowski and Barroso's persuasive argument, following Eisner [ 27] and Morse [ 28], that the explicit process of negotiating validity to consensus may ensure more validity than demonstrating inter-rater reliability since "such techniques simply show that raters can, or can be made to, agree" [[ 29], p. 807].
