On cross-validation, the extent of cortex that shows correlated time courses of neural activity while watching a movie increased by 26% after function-based alignment.
Thus, it is of paramount importance to clearly define in the VMP what has to be validated, the extent of validation required for each facility / system / equipment / analytical method, the actions to be taken in case of a significant change (e.g. the replacement of a production / quality control instrument with a different one) together with the conditions for re-validation / re-qualification.
After completion of experiments, fresh-frozen brains were cryostat-cut into coronal 20 µm sections for further validation of the extent of lesion using Cresyl violet staining, as previously described [9], [10].
Figure 1C illustrates how the reference points allowed for precise sectioning and histological validation of the extent of the demineralization extending past the DEJ of the sample.
The Space-Time Budget (STB) method as developed by Wikström et al. ([2012a]) has been validated, but the extent of validation is limited.
We selected candidate proteins for further validation based on the extent of overexpression, biological importance and available literature that validated their detection in body fluids such as CSF.
An interesting result of the validation exercise is the extent of cross-transferability of the SNPs between tall fescue morphotypes.
Some genes may differ in the frequency with which they are transcribed as polycistronic vs. independent transcripts, but these results imply that at least low levels of polycistronic transcription may be common for many genes in the genome and future validation may explore the extent of their functionality.
In these cases, however, the adoption of the ENC-DAT database in clinical use would require further validations, to assess the extent of the differences of the SBR values obtained with the different attenuation and scatter correction methods.
Images processed by AGS and manual samples of coarse-grained deposits in section were compared for evaluation of accuracy and determination of the extent of validation of the AGS technique.
The extent of validation required for screening tests may be different than that required for full replacement tests because negative compounds might still undergo full animal testing.
