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Although many advances have been made over the last decades, drug target prediction is still a very challenging task as reflected by the low clinical target validation success rate.
Thus, our validation success rate of 53% is within the expected range for this particular platform and method of validation.
Although we only selected seven NATs that scored highly in the screen for follow-up studies, our validation success rate indicates that the screening data likely contains many more examples of NATs associated with cell viability.
We then systematically assessed how technical factors influenced validation success.
We find that the WGCNA groups and markers have superior validation success.
To communicate validation success or failure and its causes, unobtrusive temporary message boxes are featured.
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One could consider developing a more nuanced DiCE scoring rubric, by attempting to quantify the number of total validations or rate of validation successes within each evidence category.
Cross-validation success was highest in the El Azufre (100.0%), still good for the Cueva del Azufre (81.0%), but low in the non-toxic surface habitats (40.5%).
For validation both success and prediction rate curves were performed.
It is the desperate need for validation and success, as much as the mere ugliness, that impresses.
That's not dependent on the external validation of success or approval.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com