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Before using the German version of the PAM13 in daily practice, further validation studies on the construct validity are highly recommended.
In a recent Rapid Report by IQWiG on the validity of surrogate endpoints in oncology, data from 21 validation studies on breast cancer and colon cancer of different stages (early or advanced, with or without metastases) were examined [23].
Validation studies on the underreport rate were conducted by randomly selecting one of the monitoring sites.
However, past validation studies on the NARCOMS registry have largely supported the validity and generalisability of its findings.
Yet other validation studies on the MM3B have only used a previously validated automated system as its criterion measure (Laurent et al. 2008; Perkins et al. 2004), a method that has been questioned as not being a true gold standard (Meyer et al. 2005).
The model validation studies on an experimental system show that the model predicts the system dynamic well.
The versatility of these new markers is presented by showing the results of validation studies on sensitivity, human specificity, stability and mixture resolution.
Although this approach is practiced de facto today in some large laboratories, there are no clinical validation studies on this approach.
It is also is looking to fund validation studies on biomarkers, which can cost $1.5 million to $3 million.
Validation studies on these methods indicate that the proposed method is credible.
This approach expanded the validation studies on TOEFL (Chapelle et al. 2008).
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