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This method can be implemented in a computationally fast way (Hartlmüller, Madl, unpublished data) and is generally applicable to a wide variety of applications, including structure validation, structure calculation and docking of biomolecular complexes.
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In this work, we adopted a supervised analysis schema: l1 l2 FS regularization with double optimization framework, set in a nested cross-validation structure (l1 l2 FS ).
After processing, the resultant data was compared with the finite element method analysis for simulation model validation and structure inspection.
Accordingly, the validation of structure MRI as a marker of AD progression is the core project of the Alzheimer's Disease Neuroimaging Initiative ADNII).
The development, validation and structure of the ABC are described in our accompanying paper (Simon et al, 2012).
Design and validation of structures against blast loads are important for modern society in order to protect and secure its citizen.
In addition, we constructed homology models for five parasite HDACs to provide information for experimental validation and structure-based optimization of inhibitors.
One such approach is provided by the validation and structure-improvement tools of the MOL: PROBITY: web service.
And they could provide independent validation of structures modelled by different software implementations.
The structural quality assessment of the final models was performed using the Protein Structure Validation Suite, as described above.
Structure validation was performed with PROCHECK51.
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