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The obtained PLS-DA model was extensively validated employing two different validation strategies: (i) statistical validation employing a method based on permutation testing and (ii) external validation splitting the available data into two independent sub-sets.
Construct validity is based on validation strategies developed by psychologists, who for many years have struggled with determining whether questionnaires assessing intelligence and attitudes really measure what is intended.
The model was validated extensively using different internal and external validation strategies in accordance with the Organization for Economic Co-operation and Development (OECD) guidelines.
Such products complicate safety and efficacy evaluations, however, since most act through distinct mechanisms, which may not be fully understood, making it difficult to standardize validation strategies.
The main lesson from our validation process is the need for multiple validation strategies, including empirical validation.
Overall, this mechanistic understanding of an important viral clearance process provides the foundation for the development of science-based process validation strategies to ensure viral safety of biotechnology products.
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The above tested models performed well on mESC data using 10-fold cross-validation as a validation strategy.
Michiels, S., Koscielny, S. & Hill, C. Prediction of cancer outcome with microarrays: A multiple random validation strategy.
Three-step development, optimization and validation strategy for GC fingerprints of Brazilian commercial gasoline is described.
We also discuss the validation strategy of the type checker, including integrations with other Circus tools.
Forecast reliability and skill are evaluated for the period 1982 2011 using a rigorous leave-five-years-out cross validation strategy.
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