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For validation simulated tumours were used which were derived from real patient data (liver metastases of a colorectal carcinoma and head and neck cancer, respectively).
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The ability of the two combined models to discriminate cancer patients from healthy controls (ROC analysis), and their classification errors were estimated using bootstrap.632+ validation, simulating external validation by resampling.
Cross-validation simulates how well a model predicts new data and gives a statistical fraction of the total variation of the dependent variables that can be predicted by all the extracted components (QCUM) for the final model.
In this process, especially for future scenario simulations, the validation of simulated carbon stock in contemporary land ecosystems would be of great importance, because bias in CMIP5 historical simulations is one cause of strong variability in the simulated future changes of carbon stock within CMIP5 and LUCID-CMIP5 simulations (Brovkin et al. [2013]; Anav et al. [2013]).
The stochastic epidemiological model used for validation simulates disease progression in isolated groups of n individuals and provides the disease status of individuals (infected/not infected) over time as output.
As a validation, 2 simulated cases have been analyzed as well.
Validation on simulated data is performed before moving to experimental data.
Experimental validation of simulated adsorber/desorber beds for sorption cooling applications is essential to obtain reliable results.
The platform offers a complete approach for the method creation and validation using simulated and real tomographic images.
Section 3 presents the proposed two-step feature ranking and selection framework, including the model formulations and model validation using simulated datasets.
The first is that the data used for validation is simulated and therefore can be chosen to have desired levels of noise.
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