What will validation validate?
Our findings have important implications for integrating hPSC-derived atrial CMs into high-throughput screenings for selection and validation of lead compounds during early stages of drug discovery.
Here, we will present a number of recent examples of fragment-based approaches to the discovery of kinase inhibitors, detailing the construction of fragment-screening libraries, the identification and validation of fragment hits, and their optimization into potent and selective lead compounds.
Like all predictive models, this would act as a pre-screening method before in vivo validation of interesting targets.
Finally, some of the hit sets listed in Table 1 were obtained directly from primary screenings, and some were filtered with additional validation assays.
For the external validation study, we included only patients with complete CAM-ICU screenings and those who were treated with haloperidol for delirium.
To meet the same inclusion and exclusion criteria during the external validation study, we used consecutive patients with complete CAM-ICU screenings, defined as a CAM-ICU compliance rate above 80% per patient.
Since this tool is considered a pre-screening tool, as opposed to a decision tool, and meant to provide a preliminary eligibility for study coordinators, ASAP does demonstrate functional ability for screening, based on a previous validation studies of the prediction tool, [ 37].
Although the Brief Symptom Inventory-18 (BSI-18) has been widely used for mental health screenings in both clinical and non-clinical populations, the validation of its application to Chinese populations has been very limited.
Schematic representation of the simulated virtual-screening (VS) experiment with the three steps scoring, validation and analysis.
