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Unfortunately software can have bugs, and if the validation routine does not report any validity errors, this could indicate that either the diagram is indeed correct (true negative), or that there is a bug in the software encoding the rules (false negative).
Cas9-based editing technology should streamline the generation of animal and cell-line models, make the generation of activity-dead mutations in target validation routine, and enable the discovery of a new generation of targets across therapeutic areas.
Smaller steps yield more responsiveness, as control is given back promptly to the IDE, however, they can cause a certain performance penalty because of the frequent calls to the validation routine.
The 'estimated degrees of freedom' (edf) that most optimally fit the data was selected from a cross validation routine implemented in the mgcv-package.
The degree to which model parameters are constrained is determined through a 10-fold cross validation routine included in this package.
We selected a smoothing parameter value of 3.2 to predict rate changes in our dataset by using r8s's cross validation routine.
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Predictions are visualized by an application GUI or serve as input for validation routines.
OpenTox provides scientifically sound validation routines for the determination of these measures.
Within OpenTox we have also implemented basic validation routines, simple validation (with supplied test set or training/test split), cross-validation routines (including leave-one-out), as well as making initial reporting routines available.
OpenTox provides unified and objective validation routines for model and algorithm developers and for external (Q SAR programs.
For this reason OpenTox provides standardized validation routines within the framework that can be applied to all prediction algorithms that are plugged into the system.
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