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To improve performance and availability of Laribus, clients can retrieve certificates signed by other groups, certificate validation records (CVR), from the DHT instead of issuing a direct query (cf. Section 1).
The 95% prediction interval (-3 to 2.6) is presented in figure 2. A ratio of 1 (or log ratio = 0) would indicate perfect agreement between self report and validation records.
Other potential confounders and biases are that we excluded those who died during the follow-up, the collection of incident fractures is captured in retrospect, the validation records was only for patients with fractures and, as well, usually the electronic registers of fracture tends to be less records than actually occur.
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Table 3 Certificate validation record storage format Row type Certificate Server Timestamp Validation S H A 256(c e r t X ) (mathcal {SRV}_{X}) t x ⏟ Signature s i g grp.
If the suspect case was not seen, the validating MO retained Part 2. If the validating MO, PHC pharmacist or PHC PMW did not note the result of validation on Part 1 of the form, still attached to the suspect referral book, there would be no validation record at the PHC clinic as Part 2 was often given to the patient as a record of the result (and to be used as a personal treatment card).
Note that the variant at chr6:31106500 had a dbSNP validation record but was included in the Sanger-sequencing as a control; this variant was observed in four populations.
Last, to validate our filtered set of HLOF variants, we Sanger-sequenced any novel variants that we detected in our samples; these included 33 variants which were neither found in the set of HLOF variants of (2) nor (7), and had no validation record in dbSNP.
CVSP validation works record by record and takes input files in MOL, SDF, and ChemDraw CDX formats.
Within the 1200 record validation set, 355 records (30%) were Read coded by the treating GP at the time of the consultation.
For validation purposes, records will be reviewed by a rheumatologist for the six months following PMR diagnosis.
When performing a validation with records not used in the phase of development, the different allocation of probability determines in our case a conservation of a similar discrimination but that the calibration is different (being better for the AC).
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