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Formal ontological mapping of all metadata terms ensured logical validation of the underlying concepts while enabling the addition of semantic relations.
Besides providing spatial predictions of soil water retention at the catchment scale, the study presents a detailed methodological insight to model setup and validation of the underlying machine learning approach with random forest.
Both of these previously reported studies (Peters et al. 2000; Vedal et al. 2004) focused on ICD therapeutic discharge without characterization or validation of the underlying arrhythmia.
In addition, individual-level patient data were not available from the London, Ontario cohort, which prevented precise baseline matching between the two cohorts, limiting our validation of the underlying (Markov) model for disease progression.
A problem with any 'history of ideas' approach is the validation of the underlying assumption that the concept one is studying has indeed continuity over the history of philosophy.
The high degree of consistency between the tasks provides a validation of the underlying method and confirms that subjects maintained fixation during the active tasks.
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Further studies are needed for validation, for exploration of the underlying pathophysiology, and for evaluation of the clinical utility of measuring cathepsin S.
Of particular interest, MET, B7-H1, CANXA1andA1 and VEGF-C all showed significant, highly prognostic effects in cohorts containing over 100 cases but still require validation and/or elucidation of the underlying biology.
The significance of these aberrations and the validation of the genes underlying the copy number changes remains to be assessed through comprehensive functional and nucleotide level sequence analysis.
However, the interpretation of DTI indices with respect to pathology is notoriously ambiguous and more validation studies to the underlying causes of DTI changes are necessary.
Furthermore, simulated dynamics and experimental validation of a regulatory core of the underlying gene-regulatory network revealed a negative-feedback loop that limits initial inflammation via hypoxia-mediated upregulation of Il10.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com