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As a further validation of the assumption of independence of the variability response function to the stochastic parameters of the problem, the concept of the generalized variability response function was applied and compared to the steady state dynamic variability response function.
However, the methodological limitations described above do not allow validation of the assumption that increased venous resistance is the only cause of high PCP levels in patients with pulmonary hypertension.
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Moreover, for all the monotonicity constraints a validation of the assumptions will be conducted based on the corresponding unconstrained model effects.
Finally, the checking process culminates in validation of the assumptions implicit in the analysis computations.
However, testing or the validation of this assumption can be hampered by the small number of cycles a patient may undertake, and so violations are often undetected.
While the general clinical lore suggests that early intervention benefits treatment outcome, the empirical validation of this assumption is inconclusive.
A problem with any 'history of ideas' approach is the validation of the underlying assumption that the concept one is studying has indeed continuity over the history of philosophy.
When the RTI process is repeated, the descriptions of the technologies are updated, giving improved indication of the technology's potential future development and validation to the assumptions of the previous round.
In future work, a validation of this assumption would be valuable.
Further work will incorporate designs that formally include validation of this assumption.
Thus, validation of the two assumptions employed for simplification of the simulation model is required to ensure the accuracy of the estimated FDRs.
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