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Prognostic data set have been used for validation of prognostic significance of gene sets e.g. representing a certain pathway.
The developed method can be used for validation of functional significance of suggested eQTLs and a discovery of new regulatory modules.
The developed method can be used for validation of functional significance of suggested eQTLs and a discovery of new regulatory interactions.
These results serve as a further validation of the significance of the identified combinations, as well as an indication of the biological function that can be attributed to each CDS.
In the absence of validation, the significance of the AGI is not known, and variation cannot be assumed to be related to hormonal exposure.
Biological processes were ranked according to their significance of enrichment, and the validation mode measure of significance was used to identify those of greatest enrichment.
Therefore, the aim of our study was the validation of the prognostic significance of NLR in a large cohort of RCC patients.
'Misinterpretation can cause potential psychological, social, and economic harm – especially before validation of the clinical significance of the findings.
Furthermore, functional follow-up tests will be necessary for a full validation of their adaptive significance (Lang et al. 2012).
For further validation of the prognostic significance of miR-200a expression in an independent data set, we also analysed RNA seq data from the TCGA data set.
NetHiKe comprises three steps: mapping the input genes onto the network, a node-limited betweenness centrality (nlBC) calculation, and validation of the statistical significance by simulated p-values.
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