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Similar to cancer research, the identification and validation of pathology-associated targets is of fundamental importance to antibody development.
In future studies, such results demand further validation by pathology.
For the purpose of later validation of a parameter for progression of pathology, to be derived from computerised image analysis, based on the measurements acquired, sections were grouped using histopathological criteria, as follows: N: normal artery: intima only a few cells in width along full circumference.
This study would open the way to further validation of this tracer for assessing pathologies for which the expression of this receptor is modified.
We believe that this was a strong validation of our analytical approach as myelodysplasia is a preleukemic disorder with varying levels of pathology and can have cases that are genetically very similar to normal hematopoietic stem cells [24].
For specificity and sensitivity validation, fluorescence stereomicroscopy of imaging ex vivo data is compared directly to histology results by accurate registration of pathology sections (<1 mm resolution) and evaluation by a gastrointestinal pathologist.
He was Director of Pathology from 1981 through 1994.
Age 47. Professor of Pathology at Drexel University College of Medicine.
Unfortunately this standard validation approach cannot completely eliminate false positive conclusions, and it can also mask many true associations that might otherwise advance our understanding of pathology.
Each part of the study included an independent cohort of patients, thus allowing for intrastudy validation of CTSE as a marker for the respective pathologies.
Methods of validation of accuracy were defined in the protocol and included pathology, therapeutic response, imaging, clinical follow-up and concordance between CIm and PET.
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