Thank you for sending your work entitled "Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data" for consideration at eLife.
Remarkably, this kind of approach has already led to the identification and experimental validation of novel therapeutic indications for the antiepileptic topiramate in inflammatory bowel disease (IBD) [6].
Repurposing or repositioning of existing drugs could overcome some of these obstacles and help in the rapid discovery and development of therapeutics for EVD, although this approach does not negate the need for some preclinical studies and clinical trials for validation of the proposed indications.
These results contribute to the scientific validation of the antialcoholic indication of this botanic species in Argentine folk medicine.
Although more studies and clinical validation of let-7b and miR-21 indications are necessary, these early works suggest ways in which miRNA biomarkers could complement current clinically used protein markers to improve prognostic assessment and to guide treatment decisions.
Strengths of our study include extensive efforts to minimise confounding, including both "healthy user" bias and confounding by indication, and the validation of all pneumonia outcomes.
Two indications provide early external validation of the translation used at the Akershus University Hospital.
Similarly, sensitivity analysis is not a true validation of the data but does give an indication of the quality of diagnoses.
The need for manual validation of the scanned PROs is an important indirect indication of the patient's general ability to correctly fill in the PRO, and also provides information about the workload of the manual validation required.
Finally, the validation of the coupled wheel-structure disturbance model is presented, giving indication of the level of accuracy that can be achieved with this type of analyses.
Our analyses of GLTPi, which maps to locus 11p15.1 of chromosome 11, provide a clear indication of the challenges associated with definitive validation of pseudogene transcription.
