Nonetheless, both cross validation of factor solutions and confirmative factor analysis is recommended to confirm the factor structure that we found.
The same set of cDNA was subsequently used for validation of transcription factors and 19/57 of the transiently upregulated genes were reproducible.
Subsequent international collaborative studies demonstrated that protocol standardization and establishment and validation of conversion factors (CFs) between field methods and IS Reference Laboratories improved harmonization and MMR concordance rates.
The prediction and validation of these factors may increase the understanding of evolution of microRNA-controlled regulatory relationships and give insight into the origins of microRNA networks in diverse animal species.
The major focus is discovery and validation of genetic factors that modify risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers, with consideration of risk stratified by tumor histologic features.
The efforts here to describe this decision making process, leading to future validation of those factors other than risk that might be associated with positive or adverse outcomes, is of benefit for a range of applications.
Finally, external validation of these factors was performed by correlation of the subscales with the subscales of the SOC questionnaire [ 12, 16] taking into account the results of Sjöström et al. [ 13], who found that women's SOC is an indicator of their capacity to cope with the process of childbearing.
In contrast to the number of in silico annotated putative TAP very few of them have been analysed at the molecular level, essentially histones and proteins involved in epigenetic regulation, highlighting that molecular validation of the factors has to be expanded.
In addition to individual's risk assessment, considering high costs and often toxic side-effects of novel drugs, an accurate identification and validation of prognostic factors will enable a better risk-stratified patient selection for adjuvant treatment modalities (Crispen et al, 2008).
These are prime candidates for experimental validation of transcription factor binding sites in this single-celled eukaryotic parasite.
