Your English writing platform
Discover LudwigSuggestions(1)
Exact(7)
Validation of association found with TLR5 in 269 RA patients treated with anti-TNF from Sweden did not confirm our initial findings (Fisher's exact test p = 0.63).
In short, I think validation of association signals in a replication set of samples is needed.
This reproduces the methodology of the original report 4 and represents an independent validation of association with LoA.
Connecting animal phenotypes associated with the QTL anchored on genomic sequence level with putative underlying genes would accelerate the identification of sequence polymorphisms and gene variants and the development of SNP markers for validation of association substantially.
This closely reproduces the methodology of the previously reported association of rs28357094 genotype with LoA in 106 Italian patients, 4 representing an independent validation of association with this phenotype.
Genotyping of individual single-nucleotide polymorphisms (SNPs) to attempt validation of association was performed with allele-specific fluorescent probes in Taqman® SNP Genotyping Assays (C_334499_10 for rs723149 from Applied Biosystems, Foster City, CA, USA) as recommended using a 96-well format.
Similar(53)
In our study design, we emphasized replication of genetic associations in independent cohorts, as opposed to reliance on statistical corrections for multiple testing, for validation of associations in the ALSPAC discovery cohort.
The genome positions where QTL were reported a number of times in studies using different sources of high seed protein and oil germplasm should be good candidates for the validation of associations detected via GWAS.
Accurate validation of associations between biomarkers and survival was attained using LOOCV discriminant analysis[ 40] that allows the assessment of the performance of biomarkers to classify individuals into high and low hazard (low and high survival, respectively).
The new transformation of genetic epidemiology has led to a new mode of discovery and validation of associations based on shear massive testing (large-scale studies on large-scale massive-testing platforms) (McCarthy et al., 2008).
Often, because of this limitation, pharmacogenomics researchers focus on functional validation of associations in cell lines (Welsh et al. 2009; Duan et al. 2009; Huang et al. 2007; Matsson et al. 2012; Ingle et al. 2010) or model systems, rather than replication of effects.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com