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If particular disease specific therapies emerge prior to the validation of associated disease biomarkers the use of cerebral biopsies may become an important tool in the diagnosis of neurodegenerative diseases in life.
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For several of these array based experimental data, RT-PCR based validations for sets of associated representative genes were reported by the submitting authors.
Fig. 3 Distribution of 670 ChEMBL compounds labelled as drug in clinical trial or as approved drug used in validation study according to number of associated targets.
It has a level of validation associated with these agencies.
The analogy of the scientific method helps break the technology and nomenclature barrier associated with a more computer science-driven approach to systems validation by associating the importance of validation to the process of designing a research plan.
Functional validation of individual genes associated with root development through knockout or gain-of-function mutants still holds merit.
To complement this analysis, we implemented secondary validation of MS/MS spectra associated with local single peptide hits using de novo peptide sequencing followed by MS-driven BLAST searching [30].
The number of patients remains too small and the time of follow-up too limited for a definitive validation of the outcomes associated with chromosomal risk profiles.
It should be noted that careful selection and validation of the genes associated with ASD and the AVs themselves provided by the authors of the initial datasets [ 41, 42] compensated for the small size of the AV set.
Due to the increasing prevalence of Mycobacterium tuberculosis strains resistant to one or more antibiotics, there is a need for new quantitative culture methods both for drug susceptibility testing and for validation of mutations putatively associated with drug resistance.
The objective is to evaluate the departure from the target reliability index analytically when this calibrated resistance factor is applied to validation cases associated with a range of COVs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com