The validation step of this classifier is performed using classical Leave-One-Out cross-validation, much more precise than a -fold cross-validation and hence not requiring any test step [13].
Media Placements: Talking about how great you are is one thing, but getting third party validation is much more convincing.
In addition, the inclusion of the large number of rare transcripts in Ensembl significantly increased program runtime and made validation events much more challenging to interpret unequivocally.
Note that the results of multiple imputation distributions are clear: the multiple imputation not only improves upon single imputation, by providing better validation statistics, but the validation statistics are much more stable than those from a single imputation [ 18].
Moreover, the derivation cohort had a substantially greater proportion of women, and, as a result, an appreciably higher prevalence of the urinary tract as the primary locus of sepsis, while the validation cohort was much more diverse with respect to the primary locus of sepsis.
Methods 1, 2, 3, 4 and 6 that use cross-validation are computationally much more intensive to implement than Methods 5 and 7 that do not involve cross-validation.
Achieving an appropriate consideration of the analytical variability in assay procedures and setting acceptance criteria for analytical validations is however much more difficult than usually described.
Cross-validation methods are much more expensive in terms of CPU time than these information criteria.
Generally speaking, the generic validation of a novel technology should be performed on a larger scale, ideally in multiple laboratories (interlaboratory validation), and include a much more comprehensive investigation of the critical parameters relevant to the specific technology to provide the highest chance of detecting sources of variation and interference.
So my view is you would think when there's money to be made that people would immediately shift over to these approaches, but The Lou Adler Group has done a great job and they've got plenty of good evidence showing, and validation studies showing, how much more effective they are.
