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The latter consists of three steps: producing two rankings, one for the full term and one for the preterm neonates, of the channel combinations; selecting the channels that appear most often in the top channel combinations; and validating these selections with a cross validation methodology.
The algorithm is first validated on known protein-term associations by a 5-fold cross validation methodology.
The key problem encountered is the entry of adequate validated clinical information which is essential in this clinical trial type of validation methodology.
A major part of this paper is devoted to explaining our validation methodology.
The validation methodology and the model itself contribute towards a better understanding of modelling RE processes.
Another precondition, equivalently important, is to define an appropriate validation methodology.
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To assess overall model fit, the model was internally validated, using a cross-validation methodology.
From the methodological point of view, we used the "leave-one-out cross-validation" methodology to study how sensitive is the proposed method to detect known Wnt/β-catenin pathway target genes.
To select the optimal choice of the fictional size m given a sample of size n, we propose a nested cross-validation methodology.
To verify the accuracy of our method, we used a standard leaving-one-out cross-validation methodology [17], training on 32 times on each 31 week subset of the training data and testing on the remaining week.
All datasets were partitioned into training and test sets following the leave-one-out cross-validation methodology.
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