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Indeed, successful clinical validation may be challenging unless the biomarker is based on a robust, analytically validated platform.
Even more important, with the changes sweeping the region and a political transition looming for the Palestinians, such a validation may be the only way to preserve support among the Palestinian and Arab publics for a two-state solution.
Despite glowing reviews from customers, the lack of outside validation may be catching up to ShotSpotter.
Depending upon which country requires the document, further validation may be necessary.
Validation may be postponed until epidemiological data have been collected (Section 2.1.5 GMS TAPS 5).
Model validation may be carried out qualitatively by comparing the already established and widely accepted theory, concepts or rules.
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Alternatively, some form of cross-validation may be used to assess the 'stability' of clustering solutions (Lange et al, 2004).
Bootstrapping, a method that involves analysing subsamples from a data set, or 'leave-one out' cross-validation may be more beneficial.
Furthermore, the ranking of learning algorithms differs, suggesting that algorithms performing best in cross-validation may be suboptimal when evaluated through independent validation.
For internal validation, such as crossvalidation or split-sample validation, it may be most appropriate to draw multiple imputations in the whole dataset before separating the derivation and validation samples (approach V1 in Table 7) (O'Mahony et al., 2014).
All validation data can be accessed from PrimerBank, since the validation criteria may be different from the criteria of the users.
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