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Three of the four methods are fully validated and the validation is successful.
Validation is successful if qRT-PCR results fulfil these criteria for at least one subtype of NSCLC (AdCa or SCC).
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Internal validation was successful with polytomous c-indexes between 0.64 and 0.69.
If this independent validation were successful, a prospective validation of the miRNA candidate biomarkers would be warranted.
Because model validation was successful, we updated the model on the pooled data (n=5909) to make full use of all available information.
For 18 of these mitogenic classifier genes the RT-qPCR validation was successful and showed a highly similar trend for insulin, X10 and IGF1 conditions (Fig. 4b).
The trait-stratified GWAS screening approach followed by selected validation was successful, and we report seven novel loci which are strongly associated with autoantibodies and serum IFN-α, two important heritable subphenotypes in SLE.
qPCR validation was successful using a different set of individuals from the same cross in a different environment and year from those used for the microarray, indicating that the differentially expressed genes had relative expression levels consistent across different growing conditions and years and between different groups of individuals from the O3 × R5 F1 population.
Overall, qRT-PCR validations were successful for thirteen out of fourteen sRNAs.
If this cross-validation approach is successful, this provides evidence that we can predict human scoring of new sets of student responses to the same questions with as much confidence as we would have using human raters.
Anatomical landmarks were registered either by the pointer, the validation of which is successful if the deviation between the pointer tip position and the calibration data is 2 mm, or by the calculations of the navigation system to proceed with bone resections and implant positioning.
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CEO of Professional Science Editing for Scientists @ prosciediting.com