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The final version of the SCQ (after psychometric validation) is composed of 30 items covering 9 domains including: humanistic impact, exhaustion with caregiving role, lack of support, patient dependence, worries for the patient, perception of the care provided, financial dependence of the patient, financial impact of caregiving, overall difficulty of caregiving role.
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Instrument validation was composed of two distinct studies: an empirical evaluation of the psychometric properties of the FRAS and a comparative known-groups validation to explore the ability of the FRAS to differentiate levels of faculty assessment experience.
As previously discussed, the pedestrian validation step is composed by several validators, each one supplying a vote that is then provided to the final evaluation step.
The validation set is composed of 10,000 patterns, 5,000 from each hypothesis.
The independent validation dataset is composed of 1,618 ANZgene cases and 1,988 controls [ 12].
Validation set 2, from Lee et al. [ 10], is composed of gene expression and clinical information from 191 GBM patients (GEO accession [GSE13041]).
Validation set 1, from Freije et al. [ 7], is composed of gene expression and clinical information from 74 GBM patients (GEO accession [GSE4412]).
Validation set 3, from Murat et al. [ 8], is composed of gene expression and clinical information from 80 GBM patients (GEO accession [GSE7696]).
It is composed of four steps with possible iterations following the validation of stakeholders.
It is composed of 16 cancer-related genes, selected after a validation step on independent studies.
It is composed of three different steps: feasibility analysis, pre-design determination and simulation validation.
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