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Novel non-invasive diagnostic markers with the potential to overcome these limitations have been developed, but often lack validation in large patient cohorts.
This warrants validation in large prospective studies.
Such aims cannot be taken for granted, when local urban development plans struggle to govern even the smallest local variations, while the regeneration programmes of urban fabric in major centres seek their political validation in large scenarios and the management of big events, with little attention to the delay and neglect these are bound to cause to other projects.
Our findings warrant validation in large prospective studies where complete data on molecular subtypes are available.
Concluding, we expect that the data presented here offers promising new targets for future validation in large clinical studies as diagnosis markers or for development of therapeutic strategies.
However, such studies are typically specific to certain cancer types, and the results have limited use due to inadequate validation in large patient cohorts.
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This may also cause low statistical power of the analyses, requiring validation in larger cohorts.
These studies require validation in larger, adequately powered trials.
This will require further validation in larger prospective studies to confirm it as a possible biomarker in MM.
These findings require validation in larger prospective studies.
Conclusion:SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.
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