Although small, we believe it is interesting enough to convey the usefulness of this process for requirement validation and for implementation testing.
Figure 3 confirms that the virtual population simulations recapitulate the individual patient clinical data for the two doses of anti-PCS9 for which data were available (40 and 150 mg), providing validation for the implementation of anti-PCSK9 monotherapy and combination therapy with statins.
Again, this model can be used as an ongoing validation method, minimizing the need for implementation validation.
For example, a metric of validation for the present implementation, which relies primarily on in vitro assay data and chemical properties for predicting toxicity, would be in the context of actual toxicity measures.
The level of data validation is minimal and sufficient for testing; a comprehensive data validation approach has been outlined for implementation prior to production release.
Results of validation suggest reliability of proposed algorithm for implementation in an operational mode.
To date, there is no consensus on the principles for design, validation, and implementation of a simulation-based surgical training curriculum.
Our study provides a practical approach for the validation and implementation of a hs-cTn assay across a large North American City.
Once it is examined in more detail in a consecutive, elaborate validation study, the CAT will be available for implementation in daily clinical practice and for research purposes.
Along the lines of the recommendations from the International Ship and Offshore Structures Committee ISSCC) I.2 on Loads this paper reviews some of the recent advances in the assessment of loads for ships and offshore structures with the aim to draw the overall technological landscape available for further understanding, validation and implementation by the academic and industrial communities.
well defined standards for the exchange of data, knowledge, models and algorithms. . a unified interface to access toxicity data and in silico models; a framework for the development and validation of new (Q SAR models; a framework for the development, validation and implementation of new in silico algorithms; and.
