The best CoMFA and CoMSIA models show conventional determination coefficients R2 of 0.96 and 0.93 as well as the Leave One Out cross-validation determination coefficients Q2 of 0.64 and 0.72, respectively.
Predictor variables for hospital mortality were analysed using logistic regression with cross-validation (80% determination and 20% validation) and robust, cluster-specific (ICU site) standard errors.
At last, method validation including determination of injection precision, repeatability, and a sample stability test, was performed.
System identification for non-linear dynamical systems could find use in many applications such as condition monitoring, finite element model validation and determination of stability.
During the last decades, the use of both modelling approaches was often met with resistance, mainly because of the need of calibration, validation and determination of the level of uncertainty (e.g.: [13 15]).
Phase III (Prospective Clinical Validation and Determination of Clinical Utility).
During the last decades, the use of both modelling approaches was often met with resistance, mainly because of the need of calibration, validation and determination of the level of uncertainty (e.g.: [ 13- 15]).
The model developed in this study uses five independent factors and further work, with other large data sets from phase 1 trial centres, is required for validation and determination of its use prospectively.
Initial psychometric validation and determination of scale properties was then carried out with 20 healthy controls (mean age 8.7 ± 2.4 years, 10 female), 29 children with asthma (mean age 10.4 ± 3.3 years, 18 female), and 30 children with cystic fibrosis (mean age 11.6 ± 3.6 years, 16 female).
Cross-validation was done using the leave-one-out method and repeating the entire analysis for each iteration of the cross-validation including determination of which sequences were univariately significant.
