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In order for emerging biomarkers to progress to the clinic, it is now widely accepted that, in addition to analytical and clinical validation, demonstration of clinical utility in a level-of-evidence (LOE-1) study is necessary.
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The focus in the second half of the project is on further validation and demonstration of the methods by applying them to the broad range of IC building blocks.
This paper illustrates the design and development of an open toolkit aimed at supporting the design of different solutions for wireless mesh networking by enabling real evaluation, validation, and demonstration.
The capability of the present approach is justified by validation and demonstration problems, including the analysis of bolted and bonded joints and hybrid joints with and without considering a disbond between the adhesive and laminates.
The biotechnological production of biobased dicarboxylic acids has recently become a hot topic in industrial biotechnology, with many investments involved in the development, piloting, and validation at demonstration scale of diverse processes using renewable raw materials.
In this paper we describe the deployment, validation and demonstration of the optical integrated testbed for the "GEneralized architecture for dYnamic infrastructure SERviceS" (GEYSERS) project to accommodate such cloud based Infrastructure Services.
In contrast, validation and demonstration of equivalence is expected to be more arduous for alternative rapid enumeration methods that are technically distinct from the current standard method and that deliver results using a different metric (for example, relative light units or number of cells with enzymatic activity).
For these instruments to be useful in clinical research, they must undergo a proper psychometric validation, including demonstration of cross-sectional and longitudinal measurement properties.
In addition to appropriate validation and demonstration of clinical utility, a desirable property of a cancer biomarker molecule is its capacity to function as a therapeutic target.
The only issue is while de-risking startup's technologies attracts more funding, they require funding for validation and technology demonstration first.
The paper presents the development of air path control for a downsized SI engine, from simulation design to validation on a demonstration car.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com