However, when validating on trials 1 and 2, trial 3 was included in the full training population, which resulted in some relatedness between training and validation populations.
When validating on trials 1 and 2, trial 3 was included in the training population, which resulted in some of the animals in the validation population to be related to animals in the training population.
For the full training populations, trials 1 through 3 were included when validating on trials 4 through 8.
Underlying this approach is the assumption that diversity indices or population densities are the proper parameters for validating ecotoxicological trials that studied intragenerational effects of individual insects.
The placebo is intended to validate the trial in the case of a no-difference outcome, i.e., it helps in assessing equivalence.
To do so, we adapted the clinical composite (which has been validated in trials of chronic HF) to the evaluation of IV levosimendan in a pilot trial of acute decompensated HF (REVIVE-1).
The model, which is designed to simulate exposures of people as they move through a changing air pollution field, was developed, validated, and trialed in Northampton, UK.
It has subsequently been validated against trials of IPTc [17], [19].
Until now, tests for diagnosing TB have usually been validated by trialling them on a population of animals 'known' to be either infected or uninfected (e.g., [14], [15], [16]).
All stimuli have been validated through trials with healthy controls.
